Definition: really small, family-owned, family-style, not corporate (it is an adjective)
Examples:
When I was a child, I lived in a small town. The only grocery store was a small mom-and-pop store. I never saw a large hypermarket until I was older.
When he started this advertising agency, it was just a small mom-and-pop agency. But it has grown, and now it is a large corporation employing thousands of people.